
Downstream of gene findings, ENIGMA has revealed how these individual variants – and genetic variants in general – may affect both the brain and risk for a range of diseases. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others 1, ENIGMA's genomic screens – now numbering over 30,000 MRI scans – have revealed at least 8 genetic loci that affect brain volumes. In some of the largest neuroimaging studies to date – of schizophrenia and major depression – ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In this review, we discuss recent work by the ENIGMA Consortium ( ) – a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Wright, br Jieping Ye, bs, bt and the ENIGMA Consortium Veltman, h, bk, bl Henrik Walter, bn Yalin Wang, bo Joanna M. Nichols, au, av Tomas Paus, aw, ax, ay Zdenka Pausova, az, ba Lianne Schmaal, bk, bl Gunter Schumann, u Li Shen, bb, bc Sanjay M. Martin, as Bernard Mazoyer, ar Colm McDonald, o Sarah E. Lee, an, ao, ap Scott Mackey, aq Nicholas G. Hulshoff Pol, i Norbert Hosten, ak Neda Jahanshad, a Sinead Kelly, a Peter Kochunov, al William S. Hibar, a Dominic Holland, r Martine Hoogman, aa, k Hilleke E. Grabe, ag, ah Tulio Guadalupe, y, ai Boris A. Fisher, y, k Jean-Paul Fouche, z Clyde Francks, y, k Sophia Frangou, w Barbara Franke, aa, ab, k Habib Ganjgahi, ac Hugh Garavan, ad David C. de Reus, i Sylvane Desrivieres, u Danai Dima, v, w Gary Donohoe, x Simon E. Andreassen, b, c Alejandro Arias-Vasquez, d Carrie E. See the padlock symbol shown by most browsers when you checkout.

ENIGMA T.N.T. FOR THE BRAIN FULL
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